Various clinical samples
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There is an aberrant expression of NBAT-1 in various human cancers, which was proven to limit the proliferation, invasion, and metastasis of tumour cells via multiple approaches. Most existing research focuses on sample size and discrete outcomes. Thus, a quantitative meta-analysis was performed to elucidate the prognostic value of lncRNA NBAT-1 expression in cancer patients.
12p vishanshan 27-06-2024 2 1 Download
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Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the various non-cancer cellular elements intertwined with cancer cells in the tumor microenvironment.
22p vibransone 28-03-2024 2 2 Download
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Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies.
15p vibransone 28-03-2024 4 2 Download
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Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases.
13p visharma 20-10-2023 3 2 Download
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Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT1) and ACAT1-mediated cholesterol esterified with fatty acids (CE) contribute to cancer progression in various cancers. Our findings of increased CE and ACAT1 levels in epithelial ovarian cancer (EOC) cell lines prompted us to investigate whether such an increase occurs in primary clinical samples obtained from human subjects diagnosed with EOC.
15p viangelamerkel 27-07-2022 3 2 Download
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New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occurrence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in various kinds of tumors. However, the small sample size was the limitation for the prognostic value of SNHG7 in clinical application.
13p vielonmusk 21-01-2022 16 0 Download
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Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are a major resource of samples in clinical research.
11p visilicon2711 20-08-2021 5 1 Download
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Non fermentors are important noscomial pathogens causing opportunistic infections in immunocompromised patients. They cause infections with patients having humidifiers, ventilators and catheter devices especially in medical intensive care units. To isolate identify in which age group, sex, risk factors of non fermentative gram negative bacteria The study was performed from September 2018 to February 2019 for a period of 6 months in Department of Microbiology& Medical Intensive Care Units. The samples were inoculated on Blood agar, Mac Conkey agar and incubated at 37℃ for overnight.
11p chauchaungayxua12 29-07-2021 18 1 Download
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The present study was done to evaluate the antifungal susceptibility pattern of Candida species by Disc diffusion method which is helpful for guiding therapy. All clinical samples sent to the Microbiology laboratory were inoculated on to Blood agar and MacConkey agar. The suspected colonies of Candida were identified by Gram stain and inoculated onto CHROM Candida differential agar for speciation.
6p trinhthamhodang11 27-04-2021 11 1 Download
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The present study aims to estimate the burden of Enterococcal infection and determine its antibiogram at our multi-speciality hospital. This hospital based retrospective study was carried out in the Dept. of Microbiology, IGIMS, Patna. Isolates of Enterococci from various clinical samples were subjected to antibiotic susceptibility testing and speciation.
8p trinhthamhodang11 27-04-2021 10 1 Download
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Infections caused by Staphylococcus aureus have a poorer prognosis when the infecting strain is Methicillin-resistant Staphylococcus aureus (MRSA) additionally MRSA strains are important for their resistance to many other commonly used antibiotics. The objectives of this study were to estimate the prevalence of MRSA strains in clinical specimens and to investigate their sensitivity pattern. A total of 480 various samples received in the department of Microbiology at MIMER Medical college and hospital, Talegaon were included in the study.
7p chauchaungayxua11 23-03-2021 14 2 Download
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The main aim of this study to isolate and identify the fungi causing dermatophytosis. Also this study of dermatophytosis was carried out in the Department of Microbiology, KLE’S Dr. PrabhakarKore Hospital and Medical Research Centre Belgaum, over a Period of one year.
6p cothumenhmong9 18-01-2021 9 2 Download
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Vitamins are essential for various biological responses in the human body and various researches indicated its role in immunity. With water soluble vitamins, B complex is being the most commonly prescribed supplements in clinical practice. This study was undertaken to find out in vitro effect of water soluble vitamin B complex against antibiotics commonly prescribed for respiratory infections caused by Klebsiella pneumoniae. 50 isolates of Klebsiella pneumoniae were isolated from sputum samples and their antibiotic sensitivity patterns were performed.
6p gaocaolon9 22-12-2020 9 1 Download
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The present study was conducted for detection of inducible resistance to Clindamycin in Staphylococcus aureus isolates using D – test at Raichur Institute of Medical Sciences-teaching hospital, RAICHUR, Karnataka, India.
6p gaocaolon9 22-12-2020 22 1 Download
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Acquired resistance to carbapenems mediated by carbapenemases in gram-negative pathogens such as Escherichia coli and Klebsiella has become worldwide. Its detection is of utmost importance in deciding the most appropriate therapeutic regimen and for this we require a simple and inexpensive testing method. A total of 250 isolates which included Escherichia coli (113) and Klebsiella spp (137) were screened for meropenem resistance by Kirby-Bauer disc diffusion method.
8p gaocaolon9 22-12-2020 15 2 Download
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Beta-lactam antibiotics are the most commonly used antimicrobials against bacterial infections. In recent years, emergence of resistance to these antimicrobial agents due to production of β-lactamases has become a serious global health concern. It was reported as leading cause to ineffectiveness to antibiotic usage, increased morbidity and high cost of treatment. Extended spectrum beta-lactamases (ESBLs) detection amongst the Gram – negative bacilli is considered as an important marker of endemicity.
9p caygaocaolon8 07-11-2020 8 1 Download
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The use of sequencing technologies to investigate the microbiome of a sample can positively impact patient healthcare by providing therapeutic targets for personalized disease treatment. However, these samples contain genomic sequences from various sources that complicate the identification of pathogens.
14p vikentucky2711 26-11-2020 11 2 Download
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Extended spectrum beta lactamase producers are posing a major obstacle in the therapeutic outcome of patients. They cause enzymatic hydrolysis of the beta lactum ring, resulting in resistance to penicillins and cephalosporins. The rise in ESBL producers results in prolonged treatment which leads to increased hospital stay and financial burden on the patient. It is necessary for all the hospitals to monitor ESBL producers to formulate preventive and therapeutic measures accordingly. The study was conducted in a tertiary care hospital during the period from December 2015 to November 2016.
7p angicungduoc8 07-11-2020 15 1 Download
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The study showed that the immunochromatography assay tests were reliable and easy to use. Blood samples were collected from 175 patients presenting with typical features suggesting clinical malaria. These blood samples were subjected to various test which included thin and thick smears stained with JSB, Giemsa, Leishman, Fields stain and the other methods employed which included Arcidine orange staining, Quantitative Buffy Coat methods, immunochromatography strips – optimal and para HIT – f. Assay are used. Gene amplification technique (Polymerase chain reaction) was used.
15p nguathienthan8 20-10-2020 16 2 Download
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Carbapenems are one of the β-Lactam antibiotics with a broad spectrum of antibacterial activity. Inappropriate use of this antibiotic can produce resistance strains by production of carbapenemases enzyme. The Klebsiella pneumoniae carbapenemase (KPC) is the most important mechanism of enzymatic resistance seen in Enterobacteriaceae isolated especially Klebsiella pneumoniae. The aim and objectives of this study was isolation and detection of the Carbapenem resistant Klebsiella species strains with phenotypic methods. Out of 11248 samples, 602 Klebsiella species (33.
6p nguaconbaynhay8 13-10-2020 11 1 Download