Various essential biological pathways

BEX family genes are expressed in various tissues and play significant roles in neuronal development. A mouse model of Bex3 gene knock-out was generated in this study, using the CRISPR-Cas9 system. Transcriptomic analysis of the brain was performed to identify genes and pathways under Bex3 regulation. Essential biological functions under the control of Bex3 related to brain development were identified.

21p lyhuyenthu 31-01-2023 4 2   Download

Trichophyton rubrum (T. rubrum) is an important model organism of dermatophytes, which are the most common fungal pathogens worldwide. Despite the severity and prevalence of the infection caused by these pathogens, current therapies are not sufficient.

14p viseulgi2711 31-08-2021 11 1   Download

Stress-activated protein kinase (SAPK) signaling plays essential roles in eliciting adequate cellular responses to stresses and proinflammatory cytokines. SAPK pathways are composed of three successive protein kinase reactions. The phosphorylation of SAPK signaling components on Ser/Thr or Thr/Tyr residues suggests the involvement of various protein phosphatases in the negative regulation of these systems.

7p research12 01-06-2013 52 3   Download

enzymes are powerful biological catalysts that are essential for the proper maintenance and propagation of any organism. these properties make them excellent candidates as therapeutic targets to combat diseases of either genetic or pathogenic origin. in this regard, one goal of molecular medicine is to develop and implement effective agents that can modulate the activity of various enzymes involved in essential biological pathways. the process of developing and characterizing these small molecules, i.e., rational drug design, often requires a priori knowledge of the enzyme in question....

29p sinh_30 27-09-2010 113 14   Download