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Vasorelaxant activities
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The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+ –channels (ROCC), and store–operated Ca2+–channels (SOCC).
7p
quenchua2
15-12-2019
8
0
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The endothelium-derived hyperpolarizing factor (EDHF) response is a critical for the functioning of small blood vessels. We investigated the effect of streptozotocin-induced diabetes on the EDHF response and its possible role in the regulation of cardiac function. The vasorelaxant response to ACh- or NS309- (direct opener endothelial small- (SKCa)- and intermediateconductance (IKCa) calcium-activated potassium channels; main components of EDHF response) were measured in pressurized mesenteric arteries (diameter 300–350 lm). The response to 1 lM ACh was reduced in diabetes (84.8 ± 2.
9p
kethamoi1
17-11-2019
13
0
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Amygdalus lycioides var. horrida (Spach) Browicz (Rosaceae), also known as Prunus lycioides (Spach.) Schneid., is an endemic Iranian species of the genus Amygdalus. In Iranian traditional medicine, the aerial parts and roots of A. lycioides are used in the treatment of diabetes. Six flavonoids, i.e. quercetin 3-O-rhamnoside (1), luteolin 7-O-rhamnoside (2), isorhamnetin 3-O-rutinoside (3), kaempferol 3-O-rhamnoside (4), apigenin (5), and naringenin (6), have been isolated from the aerial parts of this plant.
6p
vitamix
15-02-2019
18
0
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IHE ACS SYMPOSIUM SERIES was first published in 1974 to provide a mechanism for publishing symposia quickly in book form. The purpose of this series is to publish comprehensive books developed from symposia, which are usually "snapshots in time" of the current research being done on a topic, plus some review material on the topic. For this reason, it is necessary that the papers be published as quickly as possible. Before a symposium-based book is put under contract, the proposed table of contents is reviewed for appropriateness to the topic and for comprehensiveness of the collection.
288p
cronus75
14-01-2013
54
7
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