When disrupted

We have reportedpreviously thatmultiple copies ofMRG19 suppressGALgenes inawild-typebut not inagal80strainof Saccharomyces cerevisiae. In this report we show that dis-ruption ofMRG19leads to a decrease in GALinduction whenS. cerevisiaeis inducedwith 0.02% but not with 2.0% galactose. Disruption ofMRG19in agal3background (this strainshows long-termadaptationphenotype)furtherdelays theGALinduction, supporting the notion that its function is important only under low inducing signals.

11p tumor12 22-04-2013 43 2   Download

Matrix metalloprotease-2 is implicated in many biological processes and degrades extracellular and non-extracellular matrix molecules. Matrix metalloprotease-2 maintains a latent state through a cysteine–zinc ion pairing which, when disrupted, results in full enzyme activation. This pairing can be disrupted by a conformational change or cleavage within the propeptide.

14p viettel02 20-02-2013 50 3   Download

5-Bromodeoxyuridine (BrdU) modulates the expression of particular genes associated with cellular differentiation and senescence when incorporated into DNA instead of thymidine (dThd). To date, a molecular mechanism for this phenomenon remains a mystery in spite of a large number of stud-ies.

10p viettel02 19-02-2013 39 3   Download