While ovarian cancer

Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who received initial debulking surgery followed by platinum-based chemotherapy can experience highly variable clinical responses. A small percentage of women experience exceptional long-term survival (long term (LT), 10+ years), while others develop primary resistance to therapy and succumb to disease in less than 2 years (short term (ST)).

17p vibransone 28-03-2024 2 1   Download

Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs.

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Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD is pathogenic BRCA1/2 mutations, while HRD phenotype is also present in patients without BRCA1/2 alterations, suggesting other unknown factors.

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Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections.

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While ovarian cancer is recognised as having identifiable early symptoms, understanding of the key determinants of symptom awareness and early presentation is limited. A population-based survey of ovarian cancer awareness and anticipated delayed presentation with symptoms was conducted as part of the International Cancer Benchmarking Partnership (ICBP).

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Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. Patients with BRCA mutant EOC, and thus a defect in the homologous recombination (HR) repair pathway, demonstrate greater clinical response to platinum and olaparib therapy than patients with BRCA wild-type EOC.

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Growth differentiation factor 15 (GDF15) has attracted much interest as a novel biomarker for epithelial ovarian carcinoma (EOC). Research focus has been directed at GDF15 as a diagnostic detection, while the prognostic determination of GDF15 in EOC patients remains to be clearly elucidated.

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Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis.

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The management of gestational ovarian cancer can be challenging because of the risk of fetal wastage, and the possibility of treatment-related complications to the fetus; it is based on insufficient data from retrospective studies and case series. Here, a literature review of the diagnostic and surgical approaches to the gestational ovarian cancer has been performed; moreover, data on safety of chemotherapeutic treatments in pregnancy, including both oncologic and fetal outcomes, have also been reviewed.

9p trinhthamhodang1 14-11-2019 26 1   Download

The evidence base that examines the cognitive implications of playing is complex and not entirely consistent. However, there is substantial evidence overall to suggest that play is a natural way of building cognitive processes, assisting learning and can even help with more complex mental health issues. However, caution should be exercised when linking play to cognitive functioning, as this can lead to the ‘instrumentalising’ of play (Lester and Russell 2008).

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If you’re like many individuals, you don’t fully appreciate how essential good credit and money management are until you need them. Perhaps you’ve been renting an apartment for several years, but now you’d like to buy a house. Maybe it’s just not worth fixing your 10-year-old car, but you need a way to get to work so you need a car loan—fast! Or suppose your house has a damaged roof and the cost of repairs exceeds your savings.

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This pamphlet is designed to highlight various "legal aspects" of United States Savings Bonds, with emphasis on tax liability and reissues. While intended primarily for lawyers, trust officers, accountants, and legal representatives of estates, it may also serve as a guide for anyone who has decisions to make concerning the disposition of outstanding savings bonds or the form of registration for new bonds. Subjects are discussed here only in summary form. The pamphlet is not intended as a substitute for complete and qualified legal advice.

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The average annual incidence rates of certain cancers, including cervical, esophageal, liver, oral cavity and pharynx, and stomach cancer were significantly higher in the poorest areas in New Jersey as compared to the wealthiest areas. Among men, lung cancer incidence rates were significantly higher in the poorest areas, while lung cancer rates for women did not differ substantially among the three poverty area groups (areas with high poverty, medium poverty, and low poverty).

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Acetaldehyde, Acrylamide, Aflatoxin, Allyl isothiocyanate, Aniline, Benzaldehyde, Benzene, Benzo(a)pyrene, Benzofuran, Benzyl acetate, Caffeic acid, Catechol, Coumarin, 1,2,5,6-dibenz(a)anthracene, Estragole, Ethyl alcohol, Ethyl acrylate, Ethyl benzene, Ethyl carbamate, Furan and furan derivatives, Furfural, Heterocyclic amines, Hydrazines Hydrogen peroxide, Hydroquinone, d-limonene, 4-methylcatechol, Methyl eugenol, Psoralens, Quercetin glycosides, Safrole While this may seem frightening, the levels of these chemicals and pesticide residues found in food are too low to affect heal...

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research for this report was conducted from november 2008 to January 2009. it consisted of an extensive review of documents and websites from governmental and non-governmental sources; in-depth interviews based on semi-structured questionnaires; and two focus groups. one focus group comprised five health care workers, while the other was composed of four hiV-positive mothers, one of whom was pregnant at the time. a total of 23 people were interviewed in six cities across argentina: buenos aires, mar del plata, montegrande, rosario, tres arroyos, and tucumán.

123p le_minh_nha 18-12-2012 57 11   Download

The second group of teachers you should avoid are those who do their job because they didn’t get the job they wanted. Their first choice was perhaps to be a musician, a philosopher, or a writer. But life is unpredictable, dreams don’t always materialise, and in order to make a living, some people accept the role of a language teacher. After a short period of frustration, most of these ‘against-their-will’ teachers will settle into their new life and excel in their profession. However, a minority do not, and will lack the essential skills for teaching a language: energy and enthusiasm.

377p quynho77 12-11-2012 51 2   Download