Wistar rat
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“Dứa tre Lão nhà quê” extract (DTLNQ extract) was intended to treat several diseases such as dyslipidemia and venous insufficiency. To provide information on the its safety, this study evaluated the subchronic toxicity of DTLNQ extract.
8p vikoch 27-06-2024 2 1 Download
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This research was carried out to evaluate the acute and sub-chronic toxicity of ‘‘Huyet phu truc u hoan’’ (HPTUH) in experimental animals. The acute toxicity was defined on Swiss mice by the Litchfield – Wilcoxon’s method and the sub-chronic toxicity on Wistar rat’s hematopoietic function, liver, and kidney functions according to the World Health Organization Guidance.
10p vikoch 27-06-2024 2 1 Download
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This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. Our result showed that Diabetna capsules had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of the livers and kidneys of Wistar rats.
9p vikoch 27-06-2024 2 1 Download
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To evaluate the acute toxicity and semi-chronic toxicity of the remedy “Bo phe dinh suyen QY” on experimental animals. Subjects and methods: The remedy “Bo phe dinh suyen QY” meeting basic standards was used to evaluate for acute toxicity in Swiss white mice, and for semi-chronic toxicity in Wistar white rats. Acute toxicity was assessed according to the Litchfield-Wilcoxon method. Sub-chronic toxicity was assessed according to the guidance of the Ministry of Health of Vietnam.
4p viohoyo 02-04-2024 3 2 Download
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The research evaluated the acute and subchronic toxicities of An Nguyet Khang tablets in experimental animals. This study was conducted to investigate the acute and subchronic toxicities of An Nguyet Khang tablets in experimental animals.
10p vilarry 12-03-2024 3 2 Download
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In view of the toxic effects of theobromine and the medicinal potentials of Vernonia amygdalina, the present study therefore evaluated the effect of ethanol leaf extract of Vernonia amygdalina on the heart, liver and kidney of theobromine intoxicated male albino rats.
9p viisac 23-09-2023 4 1 Download
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The world has already undergone several health-related upheavals that have drawn the attention among which obesity. It is an important public health problem as well in developed as in developing countries. In order to sustainably manage this disease and associated damages, medicinal plants could be an alternative solution to synthetic drugs which can present side effects.
14p viisac 23-09-2023 2 0 Download
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The main problem now is how to lead people to consume mbuja which nevertheless contains bioactive molecules, which can help in the treatment or in the prevention of some chronic diseases. In order to the valorisation of its nutraceutic property, a study on effect of mbuja oil consumption compare to palm olein and corn oils on renal and liver dysfunction factors in Rats was carried out.
7p viisac 23-09-2023 5 1 Download
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Jasminum subtriplinerve Blume Oleaceae is a herbal medicine widely used for weight loss and milk gland stimulation. Extract product has been generally used but has not much scientific evidence about its safety and effects. This study aimed to evaluate the semi-chronic toxicity and lipid-lowering effects of Jasminum subtriplinerve Blume leaf extract. The study was performed on Wistar rats and Swiss mice.
10p viberbers 09-08-2023 3 2 Download
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The renal function plays a leading role in long-term control of arterial pressure. The comparative analysis of renal cortex transcriptome in ISIAH rats with inherited stress-induced arterial hypertension and normotensive WAG rats was performed using RNA-Seq approach.
14p vinarcissa 21-03-2023 5 1 Download
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This study evaluated the anti-hemorrhoidal effect of “TRI 01” hard capsule on croton oil-induced hemorrhoids model in rats. Hemorrhoids were induced by applying 6% croton oil preparation in the anorectal region. Then, rats were randomly assigned to groups.
8p vipettigrew 15-03-2023 6 2 Download
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It has recently become obvious that the prevalence of adults with diagnosed liver diseases has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which were safe and still effective in the treatment of liver diseases.
9p vipettigrew 15-03-2023 3 2 Download
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The purpose of this study was to evaluate the subchronic toxicity of Efcovida powder through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 90 mg/kg/day and 270 mg/kg/day in 90 consecutive days based on guidance of the World Health Organization and Organisation for Economic Co-operation and Development.
8p vipettigrew 15-03-2023 3 2 Download
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The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.
5p vihermione 06-01-2023 13 3 Download
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To examine the safety of a BaciMix product, containing two strains of Bacillus subtilis BS 304.04 and Bacillus coagulans BC 304.06 on mice and rats. Materials and methods: The acute toxicity using the Litchfield Wilcoxon method on Swiss mice and semi-chronic toxicity of the BaciMix product on Wistar rats was performed.
12p viharry 15-12-2022 6 2 Download
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The metal aluminium (Al) is a well-documented neurotoxin and has been known to exacerbate excitotoxicity within the human nervous system. This present research is aimed and intended at assessing the neuroprotective effect of eugenol (EG) against the toxic effects of aluminium chloride (AlCl3) in vivo using Wistar rats as a study model.
14p viporsche 28-10-2022 5 2 Download
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The purpose of this study is to determine if STZ causes alpha-2u globulin nephropathy in male rats during an advanced stage of diabetic kidney disease. Alpha-2u globulin nephropathy, water absorption and filtration capacities (via aquaporin [AQP]-1, − 2, − 4 and − 5) and mitochondrial function (through haloacid dehalogenase-like hydrolase domain-containing protein [HDHD]-3 and NADH-ubiquinone oxidoreductase 75 kDa subunit [NDUFS]-1 proteins) were examined in STZ-induced diabetic Wistar rat model.
9p vidarwin 23-02-2022 13 1 Download
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It has been demonstrated that administration of exogenous ketone supplement ketone salt (KS) and ketone ester (KE) increased blood ketone level and delayed the onset of isoflurane-induced anesthesia in different rodent models, such as Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. The modulatory effect of adenosinergic system may have a role in the ketone supplementation-evoked effects on isoflurane-generated anesthesia.
11p vizhangzhidong 29-12-2021 5 0 Download
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In this study, protective effects of lithium borate (LTB) on spermatogenesis as well as histopathological and immunohistochemical findings of testes in experimentally induced acute Cadmium (Cd) toxicity in rats were determined. Twenty-eight male Wistar albino rats, were used, weighing 200–220 g. Rats were randomly divided into 4 groups: Control, Cd, LTB, and LTB + Cd. Rats were anesthetized with ketamine at the end of the sixth day, blood was taken from their hearts, and the rats were decapitated. Typically, the control and LTB groups exhibited similar values.
11p dolomite36 30-12-2021 9 0 Download
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The sensitivity of the medulla spinalis to ischemia and reperfusion has been shown in previous in vitro and in vivo studies. However, less is known about the effects of carvacrol administration following ischemia and reperfusion. It was hypothesized that carvacrol might have protective effects on motor neuron functionunder ischemia- and reperfusion-induced oxidative stress.
6p dolomite36 30-12-2021 5 0 Download