Zinc ions

This study aims to generate the system of histone deacetylase enzymes (HDAC) with its cofactor zinc ion using two different parameter models and application of molecular dynamic (MD) study for structure of HDAC2 and vorinostat ligand. Materials and methods: Two non-bonded models, including 12-6-4 Lennard-Jones and cationic dummy atom, were applied for building a solvation system of HDAC2 crystal structure with presence of suber-anilohydroxamic acid (SAHA) and zinc ion.

9p vihyuga 04-03-2025 4 1   Download

Đề tài nghiên cứu chế tạo thủy tinh zinc-lithium-telluroborate (ZLTB) pha tạp ion Eu3+; khảo sát cấu trúc của vật liệu; nhận định đặc điểm của môi trường cục bộ xung quanh ion đất hiếm và tính các thông số quang học của ion Eu+ trong thủy tinh. Mời các bạn cùng tham khảo nội dung chi tiết.

58p capheviahe28 01-03-2021 16 6   Download

GTP cyclohydrolase II catalyzes the hydrolytic release of formate and pyrophosphate from GTP producing 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5¢-phos-phate, the first committed intermediate in the biosynthesis of riboflavin. The enzyme was shown to contain one zinc ion per subunit. Replacement of cysteine residue 54, 65 or 67 with serine resulted in proteins devoid of bound zinc and unable to release formate fromthe imidazole ring ofGTPor from the intermediate analog, 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5¢-triphosphate. ...

7p tumor12 22-04-2013 47 3   Download

ThehadBC and hadI genes from Clostridium difficilewere functionally expressed inEscherichia coliand shown to encode the novel 2-hydroxyiso-caproyl-CoA dehydratase HadBC and its activator HadI. The activated enzyme catalyses the dehydration of (R)-2-hydroxyisocaproyl-CoA to isocaprenoyl-CoA in the pathway of leucine fermentation. The extremely oxygen-sensitive homodimeric activator as well as the heterodimeric dehy-dratase, contain iron and inorganic sulfur; besides varying amounts of zinc, other metal ions, particularly molybdenum, were not detected in the dehy-dratase....

12p awards 05-04-2013 31 2   Download

As an essential element, selenium is present in enzymes from several families, including glutathione peroxidases, and is thought to exert anticarcinogenic properties. A remarkable feature of selenium consists of its ability to oxidize thiols under reducing conditions. Thus, one mode of action recently suggested is the oxidation of thiol groups of metal-lothionein, thereby providing zinc for essential reactions.

10p awards 05-04-2013 47 3   Download

We utilized plasmon-waveguide resonance (PWR) spectroscopy to follow the effects of sphingomyelin, cholesterol and zinc ions on the binding and aggregation of the amyloidbpeptide1)40 in lipid bilayers. With a dioleoyl-phosphatidylcholine (DOPC) bilayer, peptide binding was observed, but no aggregation occurred over a period of 15 h.

14p inspiron33 26-03-2013 45 5   Download

Matrix metalloprotease-2 is implicated in many biological processes and degrades extracellular and non-extracellular matrix molecules. Matrix metalloprotease-2 maintains a latent state through a cysteine–zinc ion pairing which, when disrupted, results in full enzyme activation. This pairing can be disrupted by a conformational change or cleavage within the propeptide.

14p viettel02 20-02-2013 50 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Quinoline Group Modified Carbon Nanotubes for the Detection of Zinc Ions

6p sting09 21-02-2012 50 8   Download