Advances in the chemistry of pyrazolopyrazoles

Published data on the methods of preparation of pyrazolopyrazoles are summarized and described systematically. The title compounds are subdivided according to the position of fusion between the 2 pyrazole rings. In addition, pyrazolo[3,4-c]pyrazoles are useful for the treatment of esophageal and gastrointestinal mucosa injury9 and brain injury, 10 and also as immunostimulatory, 11 antianginal, 12 and antitumor13 agents. A review covering the literature data on the synthesis of compounds with 2 or more pyrazole rings linked to each other published before 1995 appeared in 1995.