An integrative network-driven pipeline for systematic identification of lncRNAassociated regulatory network motifs in metastatic melanoma

Melanoma phenotype and the dynamics underlying its progression are determined by a complex interplay between different types of regulatory molecules. In particular, transcription factors (TFs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) interact in layers that coalesce into large molecular interaction networks.