Transcription factor

This study aimed to estimate the allelic and genotypic frequencies of single nucleotide polymorphisms (SNPs) of MC4R (melanocortin-4- receptor gene) and PIT1 (pituitary specific transcription factor-1) genes, and their additive dominance genetic effects on production and carcass traits in Duroc pigs.

7p vibecca 01-10-2024 2 2   Download

In this study, all the expressions of Otubain-1, NF-κB2, SHPs and STATs genes, the concentrations of cytokines IL-1β, IL-6 and TNF-α and clinical features in NHL patients were examined. To the end, gene expression levels of 82 NHL patients and 56 healthy individuals were determined by quantitative real time RT-PCR and secretion of cytokines by ELISA.

10p dianmotminh02 03-05-2024 6 1   Download

Nghiên cứu này nhằm đánh giá sự biểu hiện của protein FIT (Fer-Like Fe Deficiency-Induced Transcription Factor) trong các điều kiện sắt (Fe) khác nhau kéo dài 8 và 10 ngày kết hợp với stress oxy hóa. Nghiên cứu trước đã cho thấy cây sinh trưởng trong điều kiện thiếu Fe kéo dài 10 ngày, sự biểu hiện của FIT ở mức phiên mã bị ức chế so với cây sinh trưởng trong 8 ngày ở cùng điều kiện.

7p vigojek 02-02-2024 4 2   Download

Overcoming drug resistance is critical for increasing the survival rate of prostate cancer (PCa). Doc‑ etaxel is the first cytotoxic chemotherapeutical approved for treatment of PCa. However, 99% of PCa patients will develop resistance to docetaxel within 3 years. Understanding how resistance arises is important to increasing PCa survival.

14p vielonmusk 21-01-2022 12 1   Download

Chromatin state provides a clear decipherable blueprint for maintenance of transcriptional patterns, exemplifying a mitotically stable form of cellular programming in dividing cells. In this regard, genomic studies of chromatin states within cancerous tissues have the potential to uncover novel aspects of tumor biology and unique mechanisms associated with disease phenotypes and outcomes.

15p vielonmusk 21-01-2022 14 1   Download

Loss of prostate cancer differentiation or de-differentiation leads to an untreatable disease. Patient survival would benefit if this can be prevented or reversed. Cancer de-differentiation transforms luminal-like (differentiated) adenocarcinoma into less luminal-like and more stem-like (undifferentiated) small cell carcinoma through a sequential activation of stem cell transcription factors (scTF) POU5F1, LIN28A, SOX2 and NANOG.

13p vielonmusk 21-01-2022 11 0   Download

RNA polymerase II (Pol II) is a 12 subunit protein complex from yeast to human that is required for gene expression. Gdown1 containing Pol II [Pol II (G)] is a special form of Pol II that is catalytically inactive and heavily depends on the 30-subunit Mediator complex for its activator and basal dependent function in vitro. Here we report for the first time, the identification and the generation of a 15-subunit human Mediator complex via the novel multibac baculovirus expression system that is fully responsive to Pol II (G).

9p thiencuuchu 27-11-2021 21 3   Download

Đồ án tốt nghiệp này được thực hiện với mục tiêu nhằm lấy mẫu máu gà Tàu vàng tại Trung Tâm Giống Vật Nuôi; tách chiết DNA từ mẫu máu; xác định tần số gene PIT-1 bằng kỹ thuật PCR – RFLP. Mời các bạn cùng tham khảo.

67p zhangyan 13-07-2021 20 5   Download

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a crucial transcription factor that regulates the expression of defensive antioxidants and detoxification enzymes in cells. In a previous study, we showed that expression of the Nrf2 gene is regulated by an epigenetic modification. Rauvolfia verticillata, a traditional Chinese herbal medicine widely used in China, possesses anticancer and antioxidant effects. In this study, we investigated how Nrf2 is epigenetically regulated by reserpine, the main active component in R. verticillata, in mouse skin epidermal JB6 P+ cells.

11p caothientrangnguyen 09-05-2020 16 2   Download

The basic helix-loop-helix transcription factors play important roles in diverse cellular and molecular processes. Comparative functional genomics can provide powerful approaches to draw inferences about gene function and evolution among species.

21p vishikamaru2711 29-04-2020 15 3   Download

Rapeseed (Brassica napus L.) and soybean (Glycine max L.) seeds are rich in both protein and oil, which are major sources of biofuels and nutrition. Although the difference in seed oil content between soybean (~ 20%) and rapeseed (~ 40%) exists, little is known about its underlying molecular mechanism.

15p vishikamaru2711 29-04-2020 11 0   Download

Abiotic stress severely influences plant growth and development. MYB transcription factors (TFs), which compose one of the largest TF families, play an important role in abiotic stress responses.

18p vishikamaru2711 29-04-2020 13 1   Download

GRAS transcription factor (TF) family is unique and numerous in higher plants with diverse functions that involving in plant growth and development processes, such as gibberellin (GA) signal transduction, root development, root nodule formation, and mycorrhiza formation.

14p vishikamaru2711 29-04-2020 14 2   Download

The RsMYB1 transcription factor (TF) controls the regulation of anthocyanin in radishes (Raphanus sativus), and its overexpression in tobacco and petunias strongly enhances anthocyanin production. However, there are no data on the involvement of RsMYB1 in the mechanisms underlying abiotic stress tolerance, despite strong sequence similarity with other MYBs that confer such tolerance. In this study, we used the anthocyanin-enriched transgenic petunia lines PM6 and PM2, which overexpress RsMYB1.

15p thithizone3 30-07-2019 14 1   Download

Breast cancer is the most common cancer among women and the molecular pathways that play main roles in breast cancer regulation are still not completely understood. MicroRNAs (miRNAs) and transcription factors (TFs) are important regulators of gene expression.

17p nutifooddau 27-01-2019 13 2   Download

Chapter 8 - Major shifts in bacterial transcription. In this chapter, students will be able to understand: Sigma factor switching, the RNA polymerase encoded in phage T7, infection of E. coli by phage λ,...and another contents.

40p tangtuy05 30-03-2016 51 4   Download

The main contents of this chapter include all of the following: Categories of activators, structures of the DNA-Binding motifs of activators, independence of the domains of activators, functions of activators, interaction among activators, regulation of transcription factors.

53p tangtuy05 30-03-2016 63 4   Download

Chapter 11 - general transcription factors in eukaryotes. Eukaryotic RNA polymerases, unlike their bacterial counterparts, are incapable of binding by themselves to their respective promoters. Instead, they rely on proteins called transcription factors to show them the way. Such factors are grouped into two classes: general transcription factors and gene-specifi c transcription factors (activators). In this chapter we will survey the general transcription factors that interact with all three RNA polymerases and their promoters.

38p tangtuy05 30-03-2016 80 3   Download

Phân lập và phân tích trình tự gien ,mã hóa nhân tố phiên mã thuộc nhóm dreb ở lúa liên quan đến tính chịu hạn. DRE (yếu tố/ đoạn C lặp lại đáp ứng hạn) là trật tự ADN đặc hiệu trên vùng điều khiển hoạt động gien liên quan đến biểu hiện các gien đáp ứng với các điều kiện bất lợi ngoại cảnh ở thực vật. Tất cả các yếu tố phiên mã được nghiên cứu chi tiết đặc tính ở cây mô hình Arabidopsis, lúa, ngô và các thực vật khác điều khiển biểu hiện các gien đáp ứng với điều kiện hạn, mặn và lạnh thông qua việc bám đặc hiệu vào trình tự DRE/CRT.

8p uocvongxua08 31-08-2015 62 3   Download

A novel vector platform for vitamin H-inducible transgene expression in mammalian cells have therefore designed a strategy to convert antibiotic-responsive transcription factors into gene regulation systems responsive to non-toxic biotin, also known as vitamin H.

9p thuyancn 01-06-2015 43 5   Download