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Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors

Chia sẻ: Nguyễn Tuấn | Ngày: | Loại File: PDF | Số trang:9

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The transcription factor serum response factor (SRF) regulates expression of growth factor-dependent genes and muscle-specific genes in vertebrates. Homologous factors regulate differentiation of some ectodermic tissues in invertebrates. To explore the molecular basis of these different physiological functions, the functionality of human, Drosophila melanogaster and Artemia franciscana SRFs in mammalian cells has been compared in this article. D. melanogaster and, to a lesser extend, A. franciscana SRF co-expression represses the activity of strong SRF-dependent promoters, such as those of the mouse c-fos and A. ...

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Nội dung Text: Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors

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