Báo cáo khoa học: a-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californicaand some neuronal subtypes of nicotinic acetylcholine receptors

a-Conotoxins from Conussnails are indispensable tools for distinguishing various subtypes of nicotinic acetylcholine receptors (nAChRs), and synthe-sis of a-conotoxin analogs may yield novel antagonists of higher potency and selectivity. We incorporated additional positive charges intoa-conotox-ins and analyzed their binding to nAChRs.