Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1
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Nicotine catabolism, linked inArthrobacter nicotinovorans to the presence of the megaplasmid pAO1, leads to the for-mation ofc-N-methylaminobutyrate from the pyrrolidine ring of the alkaloid. Until now the metabolic fate of c-N-methylaminobutyrate has beenunknown. pAO1 carries a cluster of ORFs with similarity to sarcosine and dimeth-ylglycine dehydrogenases and oxidases, to the bifunctional enzyme methylenetetrahydrofolate dehydrogenase/cyclo-hydrolase and to formyltetrahydrofolate deformylase.
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