Báo cáo khoa học: A novel mechanism of TGFb-induced actin reorganization mediated by Smad proteins and Rho GTPases
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In previous studies, we have demonstrated that RhoA⁄B-dependent signal-ing regulates TGFb-induced rapid actin reorganization in Swiss 3T3 fibro-blasts. Here we report that TGFbregulates long-term actin remodeling by increasing the steady-state mRNA levels of the RhoBgene in mouse Swiss 3T3 fibroblasts and human hepatoma HepG2 cells.
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