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Báo cáo khoa học: A novel prokaryotic L-arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:17

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We report the first characterization of anl-arginine:glycine amidinotrans-ferase from a prokaryote. The enzyme, CyrA, is involved in the pathway for biosynthesis of the polyketide-derived hepatotoxin cylindrospermopsin from Cylindrospermopsis raciborskiiAWT205. CyrA is phylogenetically dis-tinct from other amidinotransferases, and structural alignment shows dif-ferences between the active site residues of CyrA and the well-characterized human l-arginine:glycine amidinotransferase (AGAT).

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Nội dung Text: Báo cáo khoa học: A novel prokaryotic L-arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis

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