Báo cáo khoa học: A1–Protein Function and Ageing

An overview of the results of our association studies on candi-date genes for human longevity performed in Italian centenarians will be presented. Many genes gave negative results but others showed a positive or negative association with human longevity. Among the last ones a particular attention will be paid to the genes involved in inflammation (IL-6, IL-10, TGFbeta, TLR-4,PPARgamma2), Insulin/IGF-1 signalling pathway and lipid metabolism (Apolipoproteins, CEPT).