Báo cáo khoa học: Abstract P1 – FEBS Datta Plenary Lectureship Award P1-001 Peptide bond formation, cotranslational folding and antibiotics synergism

Ribosomes position their substrate at stereochemistry suitable for peptide bond formation, and promote substrate-mediated cata-lysis. The linkage between substrate orientation, dominated by remote interactions, and a sizable symmetrical region identified in all known ribosome structures indicates a guided rotatory motion of aminoacylated-tRNAs along a ribosomal path leadings to the advance of nascent peptides into the protein exit tunnel at an extended conformation.