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Báo cáo khoa học: Biochemical network models simplified by balanced truncation

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Modelling of biochemical systems usually focuses on certain pathways, while the concentrations of so-called external metabolites are considered fixed. This approximation ignores feedback loops mediated by the environ-ment, that is, via external metabolites and reactions. To achieve a more realistic, dynamic description that is still numerically efficient, we propose a new methodology: the basic idea is to describe the environment by a lin-ear effective model of adjustable dimensionality.

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