Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3
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The relationship between the structure of the N-terminal sequence of trans-thyretin (TTR) and the binding of thyroid hormone was studied. A recom-binant human TTR and two derivatives of Crocodylus porosusTTRs, one with the N-terminal sequence replaced by that of human TTR (human⁄crocTTR), the other with the N-terminal segment removed (trun-cated crocTTR), were synthesized inPichia pastoris.
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