Báo cáo khoa học: Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster
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In order to understand the roles of the epoxide hydrolases (EHs) in xenobiotic biotransformation in insects, we exam-ined the induction of EHs by exogenous compounds in Drosophila melangasterthird instar larvae. Among the chemicals tested, clofibrate, a phenoxyacetate hypolipider-mics drug, increased EH activity towardscis-stilbene oxide approximately twofold in larval whole-body homogenates. The same dose of clofibrate also induced glutathione S-transferase activity.
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