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Báo cáo khoa học: Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
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The nicotinamidase⁄pyrazinamidase (PncA) ofMycobacterium tuberculosis is involved in the activation of the important front-line antituberculosis drug pyrazinamide by converting it into the active form, pyrazinoic acid. Mutations in thepncA gene cause pyrazinamide resistance in M. tuber-culosis.
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