Báo cáo khoa học: Characterization of the 5¢ untranslated region of a and b isoforms of the human thromboxane A2 receptor (TP) Differential promoter utilization by the TP isoforms
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In humans, thromboxane (TX) A2 signals through two TXA2receptor (TP) isoforms, TPaand TPb,thatdiverge within their carboxyl terminal cytoplasmic (C) tail regions and arise by differential splicing. The human TP gene con-tains three exons E1–E3; while E1 exclusively encodes 5¢ untranslatedregion (UTR) sequence,E2andE3 represent the main coding exons. An additional noncoding exon, E1b was identified within intron 1. Additionally, the TP gene contains twopromoters P1 andP2 located 5¢of E1 andE1b, respectively....
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