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Báo cáo khoa học: Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori
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Metronidazole (MTZ) is widely used in combination therapies against the human gastric pathogenHelicobacter pylori. Resistance to this drug is com-mon among clinical isolates and results from loss-of-function mutations in rdxA, which encodes an oxygen-insensitive nitroreductase. The RdxA-associated MTZ-reductase activity ofH. pyloriis lost upon cell disruption. Here we provide a mechanistic explanation for this phenomenon.
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