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Báo cáo khoa học: Chromosomal protein HMGN1 modulates the expression of N-cadherin
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HMGN1 is a nuclear protein that binds to nucleosomes and alters the accessibility of regulatory factors to their chromatin targets. To elucidate its biological function and identify specific HMGN1 target genes, we gener-ated Hmgn1–⁄– mice. DNA microarray analysis of Hmgn1+⁄+ and Hmgn1–⁄– embryonic fibroblasts identified N-cadherin as a potential HMGN1 gene target.
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