Báo cáo khoa học: A1-L1 Micromechanical studies of mitotic chromosome structure

I will discuss experiments which probe the large-scale organization of mitotic chromosomes, using a combination of chemical modifi-cations and micromechanical force measurements. Restriction nucleases cause dissolution of the chromosome, indicating that DNA itself is the contiguous structural element of the chromosome. Therefore the non-DNA (i.e., protein) components must be isolated from one another, suggesting that the mitotic chromosome is best thought of as a network or gel of chromatin.