Báo cáo khoa học: Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models
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Mitochondrial cytochromecoxidase is a key protonmotive component of the respiratory chain. Mutations in the mito-chondrially-encoded subunits of the complex have been reported in associationwith a range of diseases. In this work we used yeast and bacterial mutants to assess the effect of humanmutations insubunit 1 (L196I) andsubunit 3 (G78S, A200T,DF94–F98, F251L and W249Stop).
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