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Báo cáo khoa học: DNA sequence specificity of triplex-binding ligands

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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We have examined the ability of naphthylquinoline, a 2,7-disubstituted anthraquinone and BePI, a benzo[e]pyri-doindole derivative, to stabilize parallel DNA triplexes of different base composition. 1 Fluorescence melting studies, with both inter- and intramolecular triplexes, show that all three ligands stabilize triplexes that contain blocks of TAT triplets.Naphthylquinoline has no effect on triplexes formed with third strands composed of (TC)nor (CCT)n, but sta-bilizes triplexes that contain (TTC)n....

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Nội dung Text: Báo cáo khoa học: DNA sequence specificity of triplex-binding ligands

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