Báo cáo khoa học: Functional site of endogenous phospholipase A2 inhibitor from python serum Phospholipase A2 binding and anti-in¯ammatory activity
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The functional site ofÔphospholipase A2 inhibitor from pythonÕ (PIP) was predicted based on the hypothesis of proline brackets. Using dierent sources of secretory phospholipase A2(sPLA2 s) as enzyme, and [ 3 H]arachido-nate-labelledEscherichia colias substrate, short synthetic peptides representing the proposed site were examined for their secretoryphospholipase A2(sPLA2 ) inhibitoryactivity.
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