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Báo cáo khoa học: Identification of three phases in Onconase refolding

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:8

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Onconase is an extremely stable member of the RNase A superfamily. The increase in the thermodynamic stability by 20 kJÆmol )1 in comparison to RNase A was expected to result in altered folding behavior. Despite the lack of cis-Pro residues in native Onconase, refolding at low concentrations of guanidine hydrochloride was complex and showed three kinetic phases (fast, medium, and slow), with rate constants differing by a factor of about 10 each.

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