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Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Brain serine racemase contains pyridoxal phosphate as a prosthetic group and is known to become activated by divalent cations such as Ca 2+ and Mg2+ , as well as by ATP and ADP. In vivo, brain serine racemase is also activated by a multi-PSD-95⁄discs large⁄ZO-1 (PDZ) domain glutamate receptor interacting protein (GRIP) that is usually coupled to the GluR2⁄3 subunits of the a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid Ca 2+ channel.

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Nội dung Text: Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP

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