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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:7

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One of the most important pathological features of type 2 diabetes is the formation of islet amyloid, of which the major component is amylin pep-tide. However, the presence of a natural inhibitor such as insulin may keep amylin stable and physiologically functional in healthy individuals. Some previous studies demonstrated that insulin was a potent inhibitor of amylin fibril formationin vitro, but others obtained contradictory results.

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Nội dung Text: Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation

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