Báo cáo khoa học: Molecular and functional characterization of novel CRFR1 isoforms from the skin

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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In our continued studies on corticotropin releasing factor receptor (CRFR1) signaling in the skin, we tested functional activity of CRFR1a, e, f, g and h isoforms after transfection to COS cells.Both membrane-bound and soluble variants are translatedin vivointofinal proteinproducts that undergo further post-translational modifications.CRFR1awas the only isoform coupled directly to adenylate cyclase with the exception of an artificial isoform (CRFR1h2) with the insertion of 37 amino acids between the ligand binding domain and the first extracellular loop that was capable of producing detectable levels of cyclic AMP (cAMP)....

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