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Báo cáo khoa học: Monitoring ligand-mediated nuclear receptor–coregulator interactions by noncovalent mass spectrometry

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Retinoid receptors are ligand-dependent transcription factors belonging to the nuclear receptor superfamily. Retinoic acid (RARa, b, c) and retinoid X (RXRa, b, c) receptors mediate the retinoid/rexinoid signal to the transcriptional machineries by interacting at the first level with coactivators or corepressors, which leads to the recruitment of enzymatically active noncovalent com-plexes at target gene promoters. It has been shown that the interaction of corepressors with nuclear receptors in-volves conserved LXXI/HIXXXI/L consensus sequences termed corepressor nuclear receptor (CoRNR) boxes....

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