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Báo cáo khóa học: New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors
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Melatonin is synthesized by an enzymatic pathway, in which arylalkylamine (serotonin)N-acetyltransferase cata-lyzes the rate-limiting step. Aprevious study [Khalil, E.M., DeAngelis, J., Ishii,M.&Cole, P.A. (1999)Proc.NatlAcad. Sci. USA 96, 12418–12423] reported the discovery of bromoacetyltryptamine (BAT), a new type of inhibitor of this enzyme. This compound is the precursor of a potent bifunctional inhibitor (analogue of the transition state), capable of interfering with both the substrate and the cosubstrate binding sites. ...
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