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Báo cáo khoa học: Parkinson’s disease: Levodopa-induced dyskinesia and signal transduction
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L-3,4-Dihydroxyphenylalanine (L-dopa) remains the most effective phar-macological treatment for relief of the severe motor impairments of Par-kinson’s disease. It is very effective in controlling parkinsonian symptoms in the initial phase of the disease, but its action wanes with time. Such ‘wearing-off’ imposes an escalation in the dosage of the drug, which ulti-mately fails to provide stable control of motor symptoms and results in the appearance of abnormal involuntary movements or dyskinesia....
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