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Báo cáo khoa học: Protein kinase C e phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:16

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Protein kinase Ce (PKCe) is activated by thyrotropin-releasing hormone (TRH), a regulator of pituitary function in rat pituitary GH4C1 cells. We analyzed the downstream mechanism after PKCe activation. Exposure of GH4C1 cells to TRH or a phorbol ester increased the phosphorylation of three p52 proteins (p52a, p52b and p52c) and decreased the phosphoryla-tion of destrin and cofilin.

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Nội dung Text: Báo cáo khoa học: Protein kinase C e phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone

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