Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking
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The thyrotropin receptor (TSHR) undergoes a cleavage at the cell membrane, leading to a heterodimer, comprising an aextracellular and a b-transmembrane and intracellular subunits, held togetherbydisulfidebonds.Moreover, part of the a-subunit of the receptor is shed from thyroid and transfected L cells.To understand the role of cleavage and shedding, we constructed deletion mutants starting, respectively, at the most N-terminal (S314), and C-terminal (L378) cleavage sites previously mapped, corresponding to free b1orb2-subunits without further modification of receptor structure....
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