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Báo cáo khoa học: Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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The importance of proteoglycans for secretionof proteolytic enzymes was studied in the murine macrophage cell line J774. Untreated or 4b-phorbol 12-myristate 13-acetate (PMA)-stimulated macrophages were treated with hexyl-b-D-thioxyloside to interfere with the attachment of glycosaminoglycan chains to their respective protein cores. Activation of the J774 macrophages with PMA resulted in increased secretion of trypsin-like serine proteinase activity.

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Nội dung Text: Báo cáo khoa học: Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans

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