Báo cáo khoa học: Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions
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Protein A (Spa) is a surface-associated protein ofStaphylococcus aureus best known for its ability to bind to the Fc region of IgG. Spa also binds strongly to the Fab region of the immunoglobulins bearing VH3 heavy chains and to von Willebrand factor (vWF). Previous studies have sugges-ted that the protein A–vWF interaction is important in S. aureusadherence to platelets under conditions of shear stress.
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