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Báo cáo khoa học: Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:15

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Glutamate carboxypeptidase III (GCPIII) is a metalloenzyme that belongs to the transferrin receptor⁄glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) superfamily. GCPIII has been studied mainly because of its evo-lutionary relationship to GCPII, an enzyme involved in a variety of neuro-pathologies and malignancies, such as glutamatergic neurotoxicity and prostate cancer.

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Nội dung Text: Báo cáo khoa học: Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

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