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Báo cáo khoa học: The interaction between casein kinase Ia and 14-3-3 is phosphorylation dependent
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We have previously shown that casein kinase (CK) Iafrom mammalian brain phosphorylates 14-3-3fandsisoforms on residue 233. In the present study, we show that CKIaassociates with 14-3-3 bothin vitro andin vivo. The interaction between CKIaand 14-3-3 is dependent on CKIaphosphor-ylation, unlike centaurin-a1 (also known as ADAP1), which binds to unphosphorylated CKIaon the same region.
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