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Báo cáo khoa học: The N-terminus of mature human frataxin is intrinsically unfolded
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Frataxin is a highly conserved nuclear-encoded mitochondrial protein whose deficiency is the primary cause of Friedreich’s ataxia, an autosomal recessive neurodegenerative disease. The frataxin structure comprises a well-characterized globular domain that is present in all species and is pre-ceded in eukaryotes by a non-conserved N-terminal tail that contains the mitochondrial import signal.
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