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Báo cáo khoa học: The structural basis of calpain behavior

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:2

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Calpains are intracellular Ca 2+ -regulated cysteine pro-teases which mediate regulatory cleavage of specific substrates. They cover a broad range of physiological functions including proteolysis of molecules involved in cytoskeletal organization, the cell cycle, signal trans-duction, apoptosis, and protein renewal during growth and tissue regeneration. Originally found in mamma-lian skeletal muscle then in numerous organisms inclu-ding protists and plants, their expression is ubiquitous [1,2].

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