Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature
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Cleavage of the small amyloidogenic proteinb2-microglobulin after lysine-58 renders it more prone to unfolding and aggregation. This is important for dialysis-related b2 -microglobulin amyloidosis, since elevated levels of cleaved b2-microglobulin may be found in the circulation of dialysis patients.
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