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Báo cáo khoa học: Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
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Herpes simplex virus type-1 and type-2 are highly prevalent human patho-gens causing life-long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This ini-tial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors, leading to penetration of the viral nucleocapsid and tegument proteins into the cytoplasm.
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