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Báo cáo khoa học: Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription
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Cytosine methylation at the 5-carbon position is the only known stable base modification found in the mammalian genome. The organization and modification of chromatin is a key factor in programming gene expression patterns. Recent findings suggest that DNA methylation at the junction of transcription initiation and elongation plays a critical role in suppression of transcription.
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