Báo cáo Y học: Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation
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We reported earlier that urate may behave as a pro-oxidant in Cu 2+ -induced oxidation of diluted plasma. Thus,its effect on Cu 2+ -induced oxidation of isolated low-density lipoprotein (LDL) was investigated by mon-itoring the formation of malondialdehyde and conjugated dienes and the consumption of urate and carotenoids. We show that urate is antioxidant at high concentration but pro-oxidant at low concentration.
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