
Báo cáo Y học: Implications of the simultaneous occurrence of hepatic glycolysis from glucose and gluconeogenesis from glycerol
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Glycolysis from [6-3 H]glucose and gluconeogenesis from [U-14 C]glycerol were examined in isolated hepatocytes from fasted rats. A 5 mMbolus of glycerol inhibited phosphory-lationof 40 mMglucoseby50%andglycolysis bymore than 60%, and caused cellular ATP depletion and glycerol 3-phosphate accumulation. Gluconeogenesis from 5 mM glycerol was unaected by the presence of 40 mMglucose.
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