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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation
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The disaccharide galactosea1,3galactose (theaGal epitope) is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primates organ trans-plantation. The synthesis of theaGal epitope is catalyzed by the enzyme a1,3-galactosyltransferase (a1,3GalT). To be able to control porcinea1,3GalT gene expression speci®c-ally, we have analyzed the upstreamportionof thea1,3GalT gene, and identi®ed the regulatory sequences.
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