C-Reactive Protein (CRP) levels in neonatal meningitis in England: An analysis of national variations in CRP cut-offs for lumbar puncture

: Recent National Institute for Health and Care Excellence (NICE) CG149 guidelines suggest considering performing a lumbar puncture (LP) to investigate for meningitis in early-onset sepsis in a neonate when a Creactive protein (CRP) level >10mg/L, but the evidence for this recommendation is poorly defined.